Characterizing the role of the alternative NF-κB pathway in diffuse large B-cell lymphoma
نویسندگان
چکیده
Background Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in humans and dogs and has similar biology and clinical behavior in both species. Therefore, comparative approaches in understanding the disease may be beneficial to both species. The deregulation of nuclear factor kappa B (NFB) pathway, composed of classical and alternative pathways, is important in the pathogenesis of DLBCL. However, studies have largely focused on the classical pathway and the role of the alternative pathway is incompletely understood. In this study, we characterize the alternative NFB pathway in DLBCL to test its potential as a therapeutic target.
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